Original Contribution Interactions Between Genome-wide Significant Genetic Variants and Circulating Concentrations of Insulin-like Growth Factor 1, Sex Hormones, and Binding Proteins in Relation to Prostate Cancer Risk in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium
نویسندگان
چکیده
Konstantinos K. Tsilidis*, Ruth C. Travis, Paul N. Appleby, Naomi E. Allen, Sara Lindstrom, Fredrick R. Schumacher, David Cox, Ann W. Hsing, Jing Ma, Gianluca Severi, Demetrius Albanes, Jarmo Virtamo, Heiner Boeing, H. Bas Bueno-de-Mesquita, Mattias Johansson, J. Ramón Quirós, Elio Riboli, Afshan Siddiq, Anne Tjønneland, Dimitrios Trichopoulos, Rosario Tumino, J. Michael Gaziano, Edward Giovannucci, David J. Hunter, Peter Kraft, Meir J. Stampfer, Graham G. Giles, Gerald L. Andriole, Sonja I. Berndt, Stephen J. Chanock, Richard B. Hayes, and Timothy J. Key
منابع مشابه
Association between the Asp327Asn Polymorphism of Sex Hormone-Binding Globulin Gene and Prostate Cancer
Background: By binding SHBG hormone to sex hormones, in addition to carrying them in the blood, they regulate the amount of tissue availability. Since the genetic changes in the structure of globulin affect it’s binding to hormones, so in this study the effects of single nucleotide change in exon 8 or rs 6259 in the incidence of prostate cancer is evaluated. Methods: The study populati...
متن کاملThe Impact of Combined (Aerobic-resistance) Training on Serum Levels of IGF-I and IGFBP-3 in Men with Prostate Cancer
Background & Objective: Prostate cancer is the most common cancer in men. The purpose of this study was to determine the effect of combined training (aerobic-resistance) on serum levels of insulin-like growth factor-I (IGF-I) and insulin-like growth factor-binding proteins 3 (IGFBP-3) in men with prostate cancer. Materials & Methods: 20 eligible men with prostate cancer with an average age...
متن کاملIGF1 CA-Repeat Polymorphism and Prostate Cancer Development in Isfahan Province of Iran
Background:Prostate cancer is increasing among Iranian men and gene polymorphisms may play a role in the development of prostate cancer. Insulin-like growth factor 1 (IGF1) gene polymorphisms have been deeply explored in different malignancies. In this study, we aimed to explore the association of IGF1 CA repeat length polymorphism with the risk of prostate cancer development i...
متن کاملPnm-28: Dietary Glycemic Index, Glycemic Load, and The Risk of Endometrial Cancer
Background Endometrial cancer is a hormone-dependent disease and has been consistently associated with obesity. Non genetic lifestyle factors may account for more than 75% of endometrial cancer cases and represent potential targets for prevention of this disease. Insulin resistance induced by diet may play a particularly pernicious role in the development of endometrial cancer, possibly by redu...
متن کاملANTISENSE RNA TO THE TYPE I INSULIN-LIKE GROWTH FACTOR RECEPTOR REVERSED THE TRANSFORMED PHENOTYPE OF PC-3 HUMAN PROSTATE CANCER CELL LINE IN VITRO
The insulin-like growth factor I receptor (IGF-IR) plays an essential role in the establishment and maintenance of transformed phenotype. Interference with the IGF-IR pathway by antisense causes reversal of the transformed phenotype in many rodent and human tumor cell lines. We stably transfected the PC-3 human prostate cancer cell line with an IGF-IR antisense RNA expression plasmid. The ...
متن کامل